Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease: TACT-NAGOYA-HEART

Hideo Izawa, Takahisa Kondo, Akihiko Usui, Koji Yamamoto, Satoshi Shintani, Yasuya Inden, Satoshi Isobe, Kazumasa Unno, Masahiro Kajiguchi, Tomoko Kato, Akiko Noda, Kenji Okumura, Tomoki Naoe, Junki Takamatsu, Kimihiro Komori, Yuichi Ueda, Toyoaki Murohara

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Background: Despite recent improvements in the treatments of coronary artery disease (CAD), there are a considerable number of patients who can not receive complete revascularization because of severe or total arterial occlusion. Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium. Methods and Results: The study will investigate the safety and feasibility of intramyocardial injections of ABMMCs and test the hypothesis that this treatment would promote neovascularization and improve left ventricular (LV) global and/or regional function in patients with severe CAD who have no other option. ABMMCs (∼106 cells) will be injected into the area of ischemic myocardium where the coronary artery is not graftable, in combination with bypass surgery to the other coronary branches. Myocardial perfusion and LV global and regional function will be evaluated, based on the micromanometer-tipped catheter method, single-photon emission tomography, and myocardial enhanced and color tissue Doppler echocardiography at baseline and during 12 month follow-up. Conclusions: This project will demonstrate that intramyocardial injection of ABMMCs with or without coronary artery bypass surgery could be a safe and effective method for therapeutic neovascularization, resulting in an improvement of cardiac function in patients with severe CAD.

本文言語English
ページ(範囲)1180-1183
ページ数4
ジャーナルCirculation Journal
70
9
DOI
出版ステータスPublished - 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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