Clinical significance and problems in HCV measurement--comparison of CLEIA method with PCR method

Hirotoshi Ohta, Masao Takemura, Nobuyuki Furuta, Masumi Akiyama, Yasuo Katagiri, Hazuki Ohashi, Kanako Takahashi, Kuniaki Saito, Mitsuru Seishima

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Infection of a hepatitis C virus (HCV) is confirmed by the presence of HCV antibody or HCV-RNA. Recently, a highly sensitive method to examine HCV-core antigen has been developed. In this study, to evaluate the clinical significance of HCV-core antigen determination, we examined serum HCV infection markers, HCV-core antigen, HCV-RNA (AMPLICOR) and HCV-antibody (third generation) concentrations. We determined 225 serum samples, and three patients receiving the treatment with interferon. In 102 HCV-RNA positive samples, significant correlation was observed between HCV-RNA and HCV-core antigen (r=0.734, p<0.0001). However, three out of 102 (2.9%) cases were included within the negative range of HCV-core antigen (20 fmol/l). The HCV-core antigen value in three patients receiving the treatment with interferon paralleled with the amount of HCV-RNA. The determination of HCV-core antigen by CLEIA is a useful and time-saving method, but an attention should be paid to the presence of false-negative cases.

本文言語English
ページ(範囲)813-818
ページ数6
ジャーナルRinsho byori. The Japanese journal of clinical pathology
52
10
出版ステータスPublished - 10-2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

フィンガープリント 「Clinical significance and problems in HCV measurement--comparison of CLEIA method with PCR method」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル