Clinical significance of c-reactive protein-to- albumin ratio with rectal cancer patient undergoing chemoradiotherapy followed by surgery

Shozo Ide, Yuji Toiyama, Yoshinaga Okugawa, Satoshi Oki, Hiromi Yasuda, Hiroyuki Fujikawa, Shigeyuki Yoshiyama, Junitiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki

研究成果: ジャーナルへの寄稿学術論文査読

32 被引用数 (Scopus)

抄録

Background/Aim: This study was designed to evaluate the clinical significance of the C-reactive proteinto- albumin ratio (CAR) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery. Patients and Methods: This retrospective study evaluated the correlation between CAR and prognosis in 115 patients with locally advanced rectal cancer. We also carried out subgroup analyses limited to patients with low modified Glasgow prognosis score (mGPS) (score 0) or pathological TNM stage I-II [ypN(-)]. Results: CAR exhibited significant relationships with sex, tumor invasion, recurrence, serum carcinoembryonic antigen, and mGPS. Elevated CAR was an independent prognostic factor for overall survival (OS) and disease-free survival (DFS) among all patients. Elevated CAR also predicted poor OS and DFS in patients with pathological TNM stage I-II [ypN(-)] and low mGPS score. Conclusion: CAR is a promising predictor of survival and recurrence in patients with rectal cancer treated by CRT.

本文言語英語
ページ(範囲)5797-5804
ページ数8
ジャーナルAnticancer research
37
10
DOI
出版ステータス出版済み - 10-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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