Clinical significance of discrepancy between arterial spin labeling images and contrast-enhanced images in the diagnosis of brain tumors

Takashi Abe, Yoshifumi Mizobuchi, Wataru Sako, Saho Irahara, Yoichi Otomi, Yuki Obama, Kohei Nakajima, Delgerdalai Khashbat, Mungunkhuyag Majigsuren, Teruyoshi Kageji, Shinji Nagahiro, Masafumi Harada

研究成果: Article査読

17 被引用数 (Scopus)

抄録

Purpose: In the imaging of intra-axial brain tumors, we sometimes found areas of high signal intensity around the enhanced tumor lesions on arterial spin labeling (ASL) magnetic resonance (MR) imaging. We undertook this study to investigate the relationship between high signal intensity on ASL imaging outside the area of contrast enhancement (CE) and histological diagnosis of intra-axial brain tumors. Methods: We examined images from 28 consecutive patients with intra-axial brain tumors who underwent ASL and CE MR imaging–three with low grade glioma (LGG), 13 with high grade glioma (HGG), six with metastasis, and six with primary central nervous system lymphoma (PCNSL)–and divided imaging findings into an “ASL dominant” group when hyperintensity on ASL was found outside the CE area and a “CE dominant” group when hyperintensity on ASL was not found outside the area of enhancement. We then analyzed the relationship between imaging findings and the histological diagnosis of the tumors. Results: Four cases were excluded because of poor quality of ASL images, 7 cases were classified as ASL dominant, and 17 cases were classified as CE dominant. The histological diagnoses of ASL dominant cases were LGG in 3 cases, HGG in 3 cases, and PCNSL in one case. Those of CE dominant cases were HGG in 10 cases, metastasis in 5 cases, and PCNSL in 2 cases. All cases with brain metastasis were classified as CE dominant. Conclusion: The high signal intensity outside the area of contrast enhancement is probably caused by increased perfusion or vascular proliferation, which indicates the presence of glioma or PCNSL and not metastasis. This finding indicates a new utility for ASL images in the diagnosis of brain tumors as a supplement to the conventional measurement of perfusion obtained from ASL images.

本文言語English
ページ(範囲)313-319
ページ数7
ジャーナルMagnetic Resonance in Medical Sciences
14
4
DOI
出版ステータスPublished - 13-11-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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