Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma

Nozomi Niitsu, Hirokazu Nakamine, Masataka Okamoto, Hiroko Akamatsu, Masaaki Higashihara, Yoshio Honma, Junko Okabe-Kado, Masami Hirano

研究成果: Article

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Purpose: Recently, we established an ELISA technique for measuring nm23-H1 protein in serum and found that the serum nm23-H1 level is a potential prognostic factor for patients with non-Hodgkin's lymphoma. Experimental Design: We used immunohistochemistry to examine the expression of nm23-H1 by the lymphoma cells in patients with diffuse large B-cell lymphoma (DL-BCL). Results: By analyzing a consecutive series of 172 untreated DLBCL patients, we found that 100 (58.1%) were strongly positive. The cytoplasmic nm23 expression in lymphoma cells correlated significantly with the serum nm23-H1 level. There was a significant correlation between patients with cytoplasmic nm23-positive lymphoma and those with performance status 2-4, stage III/IV, bulky mass, B symptoms, elevated serum level of soluble interleukin 2 receptor, and elevated serum level of C-reactive protein. Overall and progression-free survival rates were significantly lower in patients with nm23-H1-positive lymphomas than in those with nm23-H1-negative lymphomas. Similar difference was seen between patients with high and low serum levels of nm23-H1. Thus, the correlation between presence or absence of cytoplasmic nm23-H1 expression and serum nm23-H1 levels suggests that serum nm23-H1 is produced directly by lymphoma cells. Conclusion: We suggest that nm23-H1 expression is a prognostic factor for DLBCL, and that it is as important as serum nm23-H1, both of which are useful for planning a treatment strategy.

元の言語English
ページ(範囲)2482-2490
ページ数9
ジャーナルClinical Cancer Research
10
発行部数7
DOI
出版物ステータスPublished - 01-04-2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Niitsu, N., Nakamine, H., Okamoto, M., Akamatsu, H., Higashihara, M., Honma, Y., Okabe-Kado, J., & Hirano, M. (2004). Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma. Clinical Cancer Research, 10(7), 2482-2490. https://doi.org/10.1158/1078-0432.CCR-03-0085