Clinical significance of lymph node micrometastasis in gastric cancer

Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Akihiro Nakajo, Sumiya Ishigami, Hiroshi Okumura, Yuko Kijima, Shinichi Ueno, Shoji Natsugoe

研究成果: Review article査読

42 被引用数 (Scopus)


Recently, the existence of lymph node micrometastasis (LNM), including isolated tumor cells, has been focused on during the development of molecular diagnostic tools for lymph node metastasis in various malignant neoplasms. In particular, immunohistochemistry and reverse transcription-polymerase chain reaction have been reported to be available for the detection of LNM in gastric cancer. However, at present, the clinical significance of LNM remains unclear in patients with gastric cancer. Therefore, we cannot strategically make light of this issue in clinical management. Currently, minimally invasive treatments, such as endoscopic submucosal dissection and laparoscopic surgery with personalized lymphadenectomy, are widely performed in consideration of postsurgical quality of life (QOL). However, it is important to maintain the balance between QOL and curability when selecting surgical treatments for patients with gastric cancer. If minimally invasive surgery based on LNM status was established for patients with early gastric cancer, it could be performed safely. We reviewed the clinical significance of LNM as an important strategic target in patients with gastric cancer.

ジャーナルAnnals of Surgical Oncology
出版ステータスPublished - 02-2013

All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学


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