TY - JOUR
T1 - Clinical significance of primary tumor score determined by tumor depth and size in patients with resectable gastric cancer
AU - Haraguchi, Naoto
AU - Arigami, Takaaki
AU - Uenosono, Yoshikazu
AU - Yanagita, Shigehiro
AU - Uchikado, Yasuto
AU - Mori, Shinichiro
AU - Kurahara, Hiroshi
AU - Kijima, Yuko
AU - Nakajo, Akihiro
AU - Maemura, Kosei
AU - Ishigami, Sumiya
AU - Natsugoe, Shoji
N1 - Publisher Copyright:
© Haraguchi et al.
PY - 2018
Y1 - 2018
N2 - Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-metastasis classification, predicting disease recurrence and prognosis in patients undergoing gastrectomy is clinically difficult. We investigated the depth of tumor invasion and tumor size in resected specimens from patients with gastric cancer and assessed the clinical utility of primary tumor score (PTS) calculated by tumor depth and size as a prognostic marker. We classified 247 patients with gastric cancer into three groups based on cut-off values for deeper tumor invasion (pT2-T4) and larger tumor size (≥ 45 mm) as a PTS of 2 (both abnormalities), 1 (one abnormality), or 0 (neither abnormality). PTS correlated significantly with lymph node metastasis, lymphovascular invasion, and stage (P < 0.0001 each). Survival differences among groups based on PTS were significant (P < 0.0001). Multivariate analysis identified PTS alone as an independent prognostic factor (P = 0.0363). PTS derived from primary tumor information alone is a potentially useful marker for predicting tumor progression and prognosis in postoperative patients with gastric cancer.
AB - Although postoperative management of gastric cancer is determined by pathological stage based on the tumor-node-metastasis classification, predicting disease recurrence and prognosis in patients undergoing gastrectomy is clinically difficult. We investigated the depth of tumor invasion and tumor size in resected specimens from patients with gastric cancer and assessed the clinical utility of primary tumor score (PTS) calculated by tumor depth and size as a prognostic marker. We classified 247 patients with gastric cancer into three groups based on cut-off values for deeper tumor invasion (pT2-T4) and larger tumor size (≥ 45 mm) as a PTS of 2 (both abnormalities), 1 (one abnormality), or 0 (neither abnormality). PTS correlated significantly with lymph node metastasis, lymphovascular invasion, and stage (P < 0.0001 each). Survival differences among groups based on PTS were significant (P < 0.0001). Multivariate analysis identified PTS alone as an independent prognostic factor (P = 0.0363). PTS derived from primary tumor information alone is a potentially useful marker for predicting tumor progression and prognosis in postoperative patients with gastric cancer.
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U2 - 10.18632/oncotarget.23953
DO - 10.18632/oncotarget.23953
M3 - Article
C2 - 29492212
AN - SCOPUS:85041467993
SN - 1949-2553
VL - 9
SP - 8512
EP - 8520
JO - Oncotarget
JF - Oncotarget
IS - 9
ER -