Clinical significance of serum KL-6 in pulmonary sarcoidosis

R. Kondo, T. Horiguchi, S. Teruya, K. Banno, A. Ishibashi, Y. Sasaki, M. Handa, S. Tachikawa

研究成果: Article

抜粋

We investigated whether the level of serum KL-6 could be an activity marker for pulmonary sarcoidosis. In 33 patients with pulmonary sarcoidosis, the relationships between serum KL-6 levels and diagnostic imaging, serum angiotensin-converting enzyme (ACE) levels, serum lysozyme levels, steroid therapy, and prognosis were evaluated. There were no significant differences in the level of serum KL-6 when the patients were divided on the basis of radiographic findings, but the level of serum KL-6 was markedly elevated in some patients with stage-II pulmonary sarcoidosis. There was a significant correlation between serum KL-6 levels and the following two parameters: serum ACE and lysozyme levels. Among patients with a high initial level of serum KL-6, pulmonary sarcoidosis tended to become exacerbated within one year. Steroid therapy significantly decreased the level of serum KL-6, suggesting that the level of serum KL-6 could be an activity indicator for pulmonary sarcoidosis. Immunohistochemical staining by anti-KL-6 antibody revealed that KL-6 was localized in proliferating type-II alveolar epithelial cells.

元の言語English
ページ(範囲)823-828
ページ数6
ジャーナルNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
39
発行部数11
出版物ステータスPublished - 11-2001

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Kondo, R., Horiguchi, T., Teruya, S., Banno, K., Ishibashi, A., Sasaki, Y., Handa, M., & Tachikawa, S. (2001). Clinical significance of serum KL-6 in pulmonary sarcoidosis. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 39(11), 823-828.