Clinical significance of sIL-2R levels in B-cell lymphomas

Noriaki Yoshida, Miyo Oda, Yoshiaki Kuroda, Yuta Katayama, Yoshiko Okikawa, Taro Masunari, Megumu Fujiwara, Takashi Nishisaka, Naomi Sasaki, Yoshito Sadahira, Keichiro Mihara, Hideki Asaoku, Hirotaka Matsui, Masao Seto, Akiro Kimura, Koji Arihiro, Akira Sakai

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Elevated soluble interleukin-2 receptor (sIL-2R) in sera is observed in patients with malignant lymphoma (ML). Therefore, sIL-2R is commonly used as a diagnostic and prognostic marker for ML, but the mechanisms responsible for the increase in sIL-2R levels in patients with B-cell lymphomas have not yet been elucidated. We first hypothesized that lymphoma cells expressing IL-2R and some proteinases such as matrix metalloproteinases (MMPs) in the tumor microenvironment can give rise to increased sIL-2R in sera. However, flow cytometric studies revealed that few lymphoma cells expressed IL-2R α chain (CD25) in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), and most CD25-expressing cells in the tumor were T-cells. Distinct correlations between CD25 expression on B-lymphoma cells and sIL-2R levels were not observed. We then confirmed that MMP-9 plays an important role in producing sIL-2R in functional studies. Immunohistochemical (IHC) analysis also revealed that MMP-9 is mainly derived from tumor-associated macrophages (TAMs). We therefore evaluated the number of CD68 and CD163 positive macrophages in the tumor microenvironment using IHC analysis. A positive correlation between the levels of sIL-2R in sera and the numbers of CD68 positive macrophages in the tumor microenvironment was confirmed in FL and extranodal DLBCL. These results may be useful in understanding the pathophysiology of B-cell lymphomas.

本文言語English
論文番号e78730
ジャーナルPloS one
8
11
DOI
出版ステータスPublished - 13-11-2013
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All Science Journal Classification (ASJC) codes

  • 一般

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