Clinical study of a new injectable cephem, FK 037, for acute bacterial prostatitis

K. Suzuki, M. Horiba, K. Ishikawa, S. Katoh

研究成果: Article査読

1 被引用数 (Scopus)

抄録

FK037, a new injectable cephem antibiotic, was administered in the treatment of 13 acute bacterial prostatitis (mean age 53.5, range 30~79), and its effectiveness and safety were evaluated. The human prostatic fluid (PF) concentration of FK037 on 7 specimens 1 hour after 1 g i.v.d., was in the range of 0.87~7.47 μg/ml (mean±SD, 3.43±2.23 μg/ml), whereas, the serum concentration averaged 45.3±2.88 μg/ml, the ratio of PF/serum consequently being 0.08±0.05. In the clinical study, Ig of FK037 was administered to 13 patients by i.v.d. twice a day for 7~9 days. Bacteriological eradication on expressed prostatic secretion (EPS) was obtained for all clinical isolates which included 11 strains of Escherichia coli (MIC≤0.05 μg/ml), 2 of Enterococcus faecalis, and each one of Staphylococcus aureus and Morganella morganii. Symptomatical cure was 100% in all cases. As for safety profile, no side efects were noted. In laboratory values, slight elevation of transaminase were detected in 3 cases, but they were transient and returned to normal 1~2 weeks after completion of the therapy. We conclude that FK037 is highly effective in the treatment of acute bacterial prostatitis, and is well tolerated in comparison with other relative antimicrobials.

本文言語English
ページ(範囲)1131-1137
ページ数7
ジャーナルActa Urologica Japonica
40
12
出版ステータスPublished - 01-12-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • Urology

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