NM441, a new oral quinolone antibiotic, was administered to 74 patients with urinary tract infections at a daily dose of 100~600mg for 3~47 days. The patients evaluable according to the criteria of the Japanese UTI Committee were 60 cases, and the clinical efficacy rates were 100% (11/11) in acute uncomplicated cystitis and 63.3% (31/49) in complicated urinary tract infections. Side effects were observed in a total of 5 cases; headache and nausea in 1 and digestive symptoms in 4. Abnormal laboratory findings were observed in a total of 3 cases; an elevation of GPT in 1, elevations of BUN and serum creatinine in 1 and an elevation of serum creatinine in 1.
|ジャーナル||Japanese Journal of Chemotherapy|
|出版物ステータス||Published - 1996|
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)