TY - JOUR
T1 - Clinicopathologic correlations of stage IE/IIE primary thyroid diffuse large B-cell lymphoma
AU - Niitsu, N.
AU - Okamoto, M.
AU - Nakamura, N.
AU - Nakamine, H.
AU - Bessho, M.
AU - Hirano, M.
N1 - Funding Information:
The authors thank the following institutions for providing patient data and specimens: Kitasato University School of Medicine, Fujita Health University School of Medicine, Kanazawa University School of Medicine, Yokohama City University, Niigata University School of Medicine, Kanagawa Cancer Center. The authors thank for having had S Nakamura, Oshima, Tamaru, and Yoshino carrying out pathological diagnosis. Supported in part by a grant from the Ministry of Health and Welfare, and Grants-in-Aid for Scientific Research (C) and Cancer Research, from The Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Japan.
PY - 2007/7
Y1 - 2007/7
N2 - Background: We studied the clinicopathological characteristics and prognoses of localized stage thyroid diffuse large B-cell lymphoma (DLBCL). Patients and methods: This study included 32 patients with stage I/IIE thyroid DLBCL. Their median age was 66 years, the male/female ratio was 10/22. Results: As to the cellular immunophenotype, CD20 was positive in 31/32, CD5 in 0/32, CD10 in 4/32, CD23 in 1/32, BCL2 in 14/30, and BCL6 in 24/32. Twelve cases showed abnormal karyotypes: two cases with t(8;14)(q24;q32), four cases with 3q27, two cases with 17p11, and four cases with other abnormal karyotypes. As for treatment, eight cases were treated with chemotherapy alone and 24 cases were treated with chemotherapy followed by radiotherapy. Complete response was achieved in 94%. The 5-year progression-free survival was 84% and the 5-year overall survival was 90% with a median follow-up period of 62 months. The germinal center B-cell (GCB) type had a significantly better prognosis than the non-GCB type. Conclusion: Localized stage thyroid DLBCL is a disease with a relatively good prognosis. It is, however, a heterogeneous disease with regard to histological type and pathological state. Localized stage thyroid DLBCL has a good prognosis and it is that there are more GCB-type DLBCL lymphomas.
AB - Background: We studied the clinicopathological characteristics and prognoses of localized stage thyroid diffuse large B-cell lymphoma (DLBCL). Patients and methods: This study included 32 patients with stage I/IIE thyroid DLBCL. Their median age was 66 years, the male/female ratio was 10/22. Results: As to the cellular immunophenotype, CD20 was positive in 31/32, CD5 in 0/32, CD10 in 4/32, CD23 in 1/32, BCL2 in 14/30, and BCL6 in 24/32. Twelve cases showed abnormal karyotypes: two cases with t(8;14)(q24;q32), four cases with 3q27, two cases with 17p11, and four cases with other abnormal karyotypes. As for treatment, eight cases were treated with chemotherapy alone and 24 cases were treated with chemotherapy followed by radiotherapy. Complete response was achieved in 94%. The 5-year progression-free survival was 84% and the 5-year overall survival was 90% with a median follow-up period of 62 months. The germinal center B-cell (GCB) type had a significantly better prognosis than the non-GCB type. Conclusion: Localized stage thyroid DLBCL is a disease with a relatively good prognosis. It is, however, a heterogeneous disease with regard to histological type and pathological state. Localized stage thyroid DLBCL has a good prognosis and it is that there are more GCB-type DLBCL lymphomas.
KW - BCL-6
KW - Germinal center B cell
KW - Hashimoto's disease
KW - Thyroid lymphoma
KW - nm23-H1
UR - https://www.scopus.com/pages/publications/34547830894
UR - https://www.scopus.com/pages/publications/34547830894#tab=citedBy
U2 - 10.1093/annonc/mdm094
DO - 10.1093/annonc/mdm094
M3 - Article
C2 - 17429099
AN - SCOPUS:34547830894
SN - 0923-7534
VL - 18
SP - 1203
EP - 1208
JO - Annals of Oncology
JF - Annals of Oncology
IS - 7
ER -