Clinicopathologic study of primary gastric lymphoma of B cell phenotype with special reference to low‐grade B cell lymphoma of mucosa‐associated lymphoid tissue among the Japanese

Kayoko Akaza, Tadashi Motoori, Shigeo Nakamura, Takashi Koshikawa, Kuniyoshi Kitoh, Naoki Futamura, Tuneya Nakamura, Masaru Kojima, Makoto Kuroda, Masao Kasahara, Taizan Suchi

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Resection specimens from 83 patients with primary gastric lymphoma (PGL) of B cell phenotype at stage IE and at stage IIE, according to the Ann Arbor classification were investigated. Histologically, these lymphomas could be divided into four types: Type I lesions (n=24) were entirely made up of MALT lymphoma; Type II lesions (n=13) were predominantly MALT lymphoma containing one to a few foci of high‐grade B cell lymphoma; Type III lesions (n=22) consisted largely of high‐grade lymphoma with small areas of low‐grade MALT lymphoma; and Type IV lesions (n=24) were pure high‐grade B cell lymphoma, mostly of the large cefi type. All patients had undergone primary gastric resection, and 14 received additional chemotherapy (n=12), or both chemotherapy and radiotherapy (n=2). The survival probability was significantly higher for Types I and II lymphomas than for Types III and IV tumors (P < 0.05 by the generalized Wilcoxon test). According to The General Rules for the Gastric Cancer Study by the Japanese Research Society for Gastric Cancer, the stage of disease showed a clear distinction between each of them (P < 0.01 by the generalized Wilcoxon test). This staging method seemed to serve well as a prognostic indicator. The histological typing of the PGL of the present series also seemed to correlate with the gross appearance, pathologic stage and prognosis. Furthermore, the expression of cyclin D1, bcl‐2 and p53 protein, and PCNA was immunohistochemically investigated in 42 cases of the present series. Most of the low‐grade PGL (Types I and II) had less than 60% PCNA‐positive cells, whereas the high‐grade PGL (Types III and IV) had more than 60% positive cells. In a study for cyclin D1 protein, no cases showed the nuclear staining pattern characteristic for mantle cell lymphoma, and the cytoplasmic staining frequently observed in the node‐based large B cell lymphoma was seldom identified in the PGL. This discrepancy might suggest a lineage difference among the morphologically similar, but site‐dierent, lymphomas. On the other hand, bcl‐2 protein overexpression was almost equal in frequency between the gastric and node‐based high‐grade B cell lymphomas. This is in contrast to the reports from Western countries, in which the majority of high‐grade gastric tumors were bcl‐2 negative.

本文言語English
ページ(範囲)832-845
ページ数14
ジャーナルPathology International
45
11
DOI
出版ステータスPublished - 11-1995

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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