Clonal Analysis of Multiple Point Mutations in the N‐ras Gene in Patients with Acute Myeloid Leukemia

Kazuaki Kubo, Tomoki Naoe, Hitoshi Kiyoi, Hisashi Fukutani, Yoshiro Kato, Takashi Oguri, Shunji Yamamori, Yoshiki Akatsuka, Yoshihisa Kodera, Ryuzo Ohno

研究成果: Article査読

37 被引用数 (Scopus)

抄録

We have screened mutations of the N‐ras gene at codons 12, 13, and 61 in leukemia cells obtained from 100 patients with acute myeloid leukemia (AMD, and found mutated N‐ras alleles in 9 patients. We further analyzed the polyclonality of multiple N‐ras gene mutations in 4 AML patients. One patient, who had the monoclonal karyotype, t(11;17), had two types of double missense mutations at codons 13 and 61 in the same allele. Each of the remaining three patients, one of whom had t(15;17) with a monoclonal rearrangement of the retinoic acid receptor alpha and PML genes, carried two missense mutations in a relatively small population of leukemia cells. We have demonstrated that multiple clonality of the N‐ras gene is occasionally observed in leukemia with a monoclonal karyotype. These findings indicate that the N‐ras mutations may not always be characterized simply by an accumulative process and that the activated N‐ras gene alone is not sufficient to cause leukemia.

本文言語English
ページ(範囲)379-387
ページ数9
ジャーナルJapanese Journal of Cancer Research
84
4
DOI
出版ステータスPublished - 04-1993

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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