Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1

Takahide Nomura, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroko Nomura, Yasumichi Hagino, Keisuke Fujita, Toshiharu Nagatsu

研究成果: Article

47 引用 (Scopus)

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A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1(89%) enzymes.

元の言語English
ページ(範囲)523-527
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
191
発行部数2
DOI
出版物ステータスPublished - 15-03-1993

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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