TY - JOUR
T1 - Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1
AU - Nomura, Takahide
AU - Ichinose, Hiroshi
AU - Sumi-Ichinose, Chiho
AU - Nomura, Hiroko
AU - Hagino, Yasumichi
AU - Fujita, Keisuke
AU - Nagatsu, Toshiharu
PY - 1993/3/15
Y1 - 1993/3/15
N2 - A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1(89%) enzymes.
AB - A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1(89%) enzymes.
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U2 - 10.1006/bbrc.1993.1249
DO - 10.1006/bbrc.1993.1249
M3 - Article
C2 - 8461009
AN - SCOPUS:0027328913
SN - 0006-291X
VL - 191
SP - 523
EP - 527
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -