Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment

H. Qiao, Y. Noda, H. Kamei, T. Nagai, H. Furukawa, H. Miura, Y. Kayukawa, T. Ohta, T. Nabeshima

研究成果: Article

109 引用 (Scopus)

抜粋

Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SB deficit was observed on repeated treatment with methamphetamine for 14 days. The SB deficit produced by treatment with PCP (10mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, alone at the same treatment dose increased SB in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SB deficit.

元の言語English
ページ(範囲)11-15
ページ数5
ジャーナルNeuroReport
12
発行部数1
DOI
出版物ステータスPublished - 22-01-2001
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Qiao, H., Noda, Y., Kamei, H., Nagai, T., Furukawa, H., Miura, H., Kayukawa, Y., Ohta, T., & Nabeshima, T. (2001). Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment. NeuroReport, 12(1), 11-15. https://doi.org/10.1097/00001756-200101220-00010