Co-administration of adenovirus vector expressing CTLA4-Ig prolongs transgene expression in the brain of mice sensitized with adenovirus

Tetsuya Uchida, Koji Kajiwara, Makoto Ideguchi, Koichi Yoshikawa, Jun Morioka, Michiyasu Suzuki

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The duration of transgene expression in the brain is known to be shortened by previous sensitization to adenovirus. In order to prolong transgene expression, adenovirus vectors expressing CTLA4-Ig (AdCTLA), which blocks the B7-CD28 co-stimulatory signals required for T-cell activation, were used. Local administration of AdCTLA into the brain suppressed both the cellular and humoral immune responses to adenovirus vectors, and prolonged the duration of transgene expression. AdCTLA may be an effective tool for repeated gene transfer.

本文言語English
ページ(範囲)272-280
ページ数9
ジャーナルBrain Research
898
2
DOI
出版ステータスPublished - 20-04-2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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