TY - JOUR
T1 - Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development
AU - Kanai-Azuma, Masami
AU - Mattick, John S.
AU - Kaibuchi, Kozo
AU - Wood, Stephen A.
N1 - Funding Information:
The authors wish to thank Drs. Yoshiakira Kanai, Toshiya Yamada and Derek Kennedy for their helpful support and Dr. Neil Della for advice and comments on the manuscript. We also wish to thank Ms. Ke-lin Ru and Mr. Paul Addison for their technical support. This work was supported, in part, by an Australian National Health and Medical Research Grant to SAW and JSM.
PY - 2000/3/1
Y1 - 2000/3/1
N2 - The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF- 6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053-1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. (C) 2000 Elsevier Science Ireland Ltd.
AB - The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF- 6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053-1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. (C) 2000 Elsevier Science Ireland Ltd.
UR - https://www.scopus.com/pages/publications/0034004438
UR - https://www.scopus.com/pages/publications/0034004438#tab=citedBy
U2 - 10.1016/S0925-4773(99)00294-4
DO - 10.1016/S0925-4773(99)00294-4
M3 - Article
C2 - 10704870
AN - SCOPUS:0034004438
SN - 0925-4773
VL - 91
SP - 383
EP - 386
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 1-2
ER -