Cocaine- and amphetamine-regulated transcript

Yuki Kobayashi, Hiroshi Nagasaki, Yumiko Saito

研究成果: Chapter

抄録

CART was originally discovered as a transcript upregulated in the rat nucleus accumbens in response to cocaine and amphetamine, and the mRNA is extensively detected in the central, peripheral, and enteric nervous systems, and in endocrine tissues such as pancreatic islet cells. Variable processing by prohormone convertase enzymes gives rise to multiple CART fragments. Among them, CART55-102 and CART62-102 are thought to be the putative active peptides. The CART system has been suggested to play a role in a number of physiological and pathophysiological functions, including regulation of feeding, stress, pancreatic islet function, and many others. The most important goal is to identify the cognate receptor of the CART peptide. A recent finding suggests that CART55-102 is a ligand of GPR160. A detailed pharmacological analysis is needed to determine whether the ligand-receptor interaction is specific.

本文言語English
ホスト出版物のタイトルHandbook of Hormones
ホスト出版物のサブタイトルComparative Endocrinology for Basic and Clinical Research
出版社Elsevier
ページ137-140
ページ数4
ISBN(電子版)9780128206492
DOI
出版ステータスPublished - 01-01-2021

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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