Cocaine- and Amphetamine-Regulated Transcript

Hiroshi Nagasaki, Yuki Kobayashi, Yumiko Saito

研究成果: 書籍/レポート タイプへの寄稿

抄録

CART was originally discovered as a transcript upregulated in the rat nucleus accumbens in response to cocaine and amphetamine, and the mRNA is detected in the central, peripheral, and enteric nervous systems, and in endocrine tissues such as pancreatic islet cells. Variable processing by prohormone convertase enzymes gives rise to multiple CART fragments. Among them, CART55–102 and CART62–102 are thought to be the putative active peptides. The CART system has been suggested to play a role in a number of physiological and pathophysiological functions, including regulation of feeding, stress, and pancreatic islet function. Identification of a CART receptor(s) has had an impact on our understanding of brain function and thus on new avenues in treating disorders.

本文言語英語
ホスト出版物のタイトルHandbook of Hormones
ホスト出版物のサブタイトルComparative Endocrinology for Basic and Clinical Research
出版社Elsevier
ページ85,e10C-1-87,e10C-1
ISBN(電子版)9780128010280
ISBN(印刷版)9780128010679
DOI
出版ステータス出版済み - 01-01-2015

All Science Journal Classification (ASJC) codes

  • 医学一般

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