Coexistence of gastric- and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach

Takafumi Otsuka, Tetsuya Tsukamoto, Tsutomu Mizoshita, Ken Ichi Inada, Yoshiharu Takenaka, Sosuke Kato, Yoshitaka Yamamura, Kazumasa Miki, Masae Tatematsu

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Intestinal metaplasia (IM) in the human stomach has previously been classified into a gastric and intestinal mixed (GI-IM) and a solely intestinal phenotype (I-IM). The phenotypes of mucous and endocrine cells were evaluated in 3034 glandular ducts associated with chronic gastritis. In the pyloric region, the relative expression of gastric endocrine cell markers, such as gastrin and somatostatin, decreased gradually from glandular ducts with only gastric mucous cell phenotype (G type) to GI-IM toward I-IM, while that of the intestinal endocrine cell markers, glicentin, gastric inhibitory polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) was inversely correlated. In the fundic region, gastrin-positive cells emerged in the pseudo-pyloric and GI-IM glands, whereas I-IM glands did not possess any gastrin-positive cells, suggesting the presence of a distinct pathway of intestinalization. Double staining revealed coexistence of gastrin- and GLP-1-positive cells in the same gland and occasionally in the same cell in GI-IM glands. These results suggest that the phenotypes of endocrine cells are in line with those for mucous counterparts and support the concept that all of the different types of mucous and endocrine cells in normal and IM glands might be derived from a single progenitor cell in each gland.

本文言語English
ページ(範囲)170-179
ページ数10
ジャーナルPathology International
55
4
DOI
出版ステータスPublished - 01-04-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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