TY - JOUR
T1 - Combined fibrinogen concentration and neutrophil-lymphocyte ratio as a prognostic marker of gastric cancer
AU - Arigami, Takaaki
AU - Uenosono, Yoshikazu
AU - Matsushita, Daisuke
AU - Yanagita, Shigehiro
AU - Uchikado, Yasuto
AU - Kita, Yoshiaki
AU - Mori, Shinichiro
AU - Kijima, Yuko
AU - Okumura, Hiroshi
AU - Maemura, Kosei
AU - Ishigami, Sumiya
AU - Natsugoe, Shoji
N1 - Publisher Copyright:
© 2016, Spandidos Publications. All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - Certain patients with early gastric cancer succumb to recurrent disease and cancer-associated complications. The key cause of recurrence is challenging to determine, since clinical blood markers that are able to predict the tumor properties of gastric cancer are limited. The present study investigated the fibrinogen concentration and neutrophil-lymphocyte ratio (NLR) in blood specimens from patients with gastric cancer, and assessed the clinical applicability of combining the fibrinogen concentration with the NLR (CFS-NLR) as a prognostic marker of gastric cancer. The present study consisted of 275 patients with gastric cancer, who were divided into three groups: Those possessing hyperfibrinogenemia (≥305 mg/dl) and a high NLR (≥2.34, CFS-NLR 2 group), those possessing either hyperfibrinogenemia or a high NLR (CFS-NLR 1 group), or those that possessed neither abnormality (CFS-NLR 0 group). The CFS-NLR was significantly associated with the depth of tumor invasion, lymph node metastasis, lymphovascular invasion and tumor stage (P<0.0001). The prognostic differences among the three groups were significant (P=0.0016). Therefore, the CFS-NLR may be a potentially useful blood marker for predicting tumor progression and the prognosis of patients with gastric cancer.
AB - Certain patients with early gastric cancer succumb to recurrent disease and cancer-associated complications. The key cause of recurrence is challenging to determine, since clinical blood markers that are able to predict the tumor properties of gastric cancer are limited. The present study investigated the fibrinogen concentration and neutrophil-lymphocyte ratio (NLR) in blood specimens from patients with gastric cancer, and assessed the clinical applicability of combining the fibrinogen concentration with the NLR (CFS-NLR) as a prognostic marker of gastric cancer. The present study consisted of 275 patients with gastric cancer, who were divided into three groups: Those possessing hyperfibrinogenemia (≥305 mg/dl) and a high NLR (≥2.34, CFS-NLR 2 group), those possessing either hyperfibrinogenemia or a high NLR (CFS-NLR 1 group), or those that possessed neither abnormality (CFS-NLR 0 group). The CFS-NLR was significantly associated with the depth of tumor invasion, lymph node metastasis, lymphovascular invasion and tumor stage (P<0.0001). The prognostic differences among the three groups were significant (P=0.0016). Therefore, the CFS-NLR may be a potentially useful blood marker for predicting tumor progression and the prognosis of patients with gastric cancer.
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U2 - 10.3892/ol.2015.4049
DO - 10.3892/ol.2015.4049
M3 - Article
AN - SCOPUS:84954349633
VL - 11
SP - 1537
EP - 1544
JO - Oncology Letters
JF - Oncology Letters
SN - 1792-1074
IS - 2
ER -