TY - JOUR
T1 - Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese
AU - Akamatsu, Shusuke
AU - Takata, Ryo
AU - Haiman, Christopher A.
AU - Takahashi, Atsushi
AU - Inoue, Takahiro
AU - Kubo, Michiaki
AU - Furihata, Mutsuo
AU - Kamatani, Naoyuki
AU - Inazawa, Johji
AU - Chen, Gary K.
AU - Le Marchand, Loïc
AU - Kolonel, Laurence N.
AU - Katoh, Takahiko
AU - Yamano, Yuko
AU - Yamakado, Minoru
AU - Takahashi, Hiroyuki
AU - Yamada, Hiroki
AU - Egawa, Shin
AU - Fujioka, Tomoaki
AU - Henderson, Brian E.
AU - Habuchi, Tomonori
AU - Ogawa, Osamu
AU - Nakamura, Yusuke
AU - Nakagawa, Hidewaki
N1 - Funding Information:
of Osaka-Midosuji District 2660 Rotary International in Japan for supporting our study. This work was conducted as a part of the BioBank Japan Project that was supported by the Ministry of Education, Culture, Sports, Sciences and Technology of the Japanese government and was supported in part by a research grant from the Japan Society for the Promotion of Science (22390306 to H.N.), by the Princess Takamatsu Cancer Research Fund and by the Takeda Science Foundation. The Multiethnic Cohort (MEC) was supported by grants from the US National Institutes of Health (NIH; HG004726, CA148537, CA54281 and CA63464). S.A. is a Japan Society for the Promotion of Science Research Fellow.
PY - 2012/4
Y1 - 2012/4
N2 - We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10 -4) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10 -10; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10 -8) and 3p11.2 (rs2055109; P = 3.94 x 10 -8). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10 -7). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
AB - We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 x 10 -4) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 x 10 -10; FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 x 10 -8) and 3p11.2 (rs2055109; P = 3.94 x 10 -8). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 x 10 -7). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
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U2 - 10.1038/ng.1104
DO - 10.1038/ng.1104
M3 - Article
C2 - 22366784
AN - SCOPUS:84862825777
SN - 1061-4036
VL - 44
SP - 426
EP - 429
JO - Nature Genetics
JF - Nature Genetics
IS - 4
ER -