Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

Yukinori Okada, Michiaki Kubo, Hiroko Ohmiya, Atsushi Takahashi, Natsuhiko Kumasaka, Naoya Hosono, Shiro Maeda, Wanqing Wen, Rajkumar Dorajoo, Min Jin Go, Wei Zheng, Norihiro Kato, Jer Yuarn Wu, Qi Lu, Tatsuhiko Tsunoda, Kazuhiko Yamamoto, Yusuke Nakamura, Naoyuki Kamatani, Toshihiro Tanaka

研究成果: Article

160 引用 (Scopus)

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Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass indexĝ€"associated loci in the CDKAL1 locus at 6p22 (rs2206734, P = 1.4 - 10 g11) and the KLF9 locus at 9q21 (rs11142387, P = 1.3 - 10 g9), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 - 10 g8). We subsequently performed gene-gene interaction analyses and identified an interaction (P = 2.0 - 10 g8) between a SNP in the KLF9 locus (rs11142387) and one in the MSTN (also known as GDF8) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.

元の言語English
ページ(範囲)302-306
ページ数5
ジャーナルNature Genetics
44
発行部数3
DOI
出版物ステータスPublished - 01-03-2012

All Science Journal Classification (ASJC) codes

  • Genetics

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    Okada, Y., Kubo, M., Ohmiya, H., Takahashi, A., Kumasaka, N., Hosono, N., Maeda, S., Wen, W., Dorajoo, R., Go, M. J., Zheng, W., Kato, N., Wu, J. Y., Lu, Q., Tsunoda, T., Yamamoto, K., Nakamura, Y., Kamatani, N., & Tanaka, T. (2012). Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nature Genetics, 44(3), 302-306. https://doi.org/10.1038/ng.1086