Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

Vinod Kumar; Keitaro Matsuo; Atsushi Takahashi; Naoya Hosono; Tatsuhiko Tsunoda; Naoyuki Kamatani; Sun Young Kong; Hidewaki Nakagawa; Ri Cui; Chizu Tanikawa; Masao Seto; Yasuo Morishima; Michiaki Kubo; Yusuke Nakamura; Koichi Matsuda

doi:10.1038/jhg.2011.35

Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

Vinod Kumar, Keitaro Matsuo, Atsushi Takahashi, Naoya Hosono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Sun Young Kong, Hidewaki Nakagawa, Ri Cui, Chizu Tanikawa, Masao Seto, Yasuo Morishima, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda

研究支援推進本部

研究成果: Article › 査読

23 被引用数 (Scopus)

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Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10^-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10^-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.

本文言語	English
ページ（範囲）	436-439
ページ数	4
ジャーナル	Journal of Human Genetics
巻	56
号	6
DOI	https://doi.org/10.1038/jhg.2011.35
出版ステータス	Published - 06-2011

All Science Journal Classification (ASJC) codes

遺伝学
遺伝学（臨床）

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10.1038/jhg.2011.35

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title = "Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility",

abstract = "Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.",

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AU - Takahashi, Atsushi

AU - Hosono, Naoya

AU - Tsunoda, Tatsuhiko

AU - Kamatani, Naoyuki

AU - Kong, Sun Young

AU - Nakagawa, Hidewaki

AU - Cui, Ri

AU - Tanikawa, Chizu

AU - Seto, Masao

AU - Morishima, Yasuo

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Matsuda, Koichi

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N2 - Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.

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Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

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