Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

Vinod Kumar; Keitaro Matsuo; Atsushi Takahashi; Naoya Hosono; Tatsuhiko Tsunoda; Naoyuki Kamatani; Sun Young Kong; Hidewaki Nakagawa; Ri Cui; Chizu Tanikawa; Masao Seto; Yasuo Morishima; Michiaki Kubo; Yusuke Nakamura; Koichi Matsuda

doi:10.1038/jhg.2011.35

Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

Vinod Kumar
, Keitaro Matsuo
, Atsushi Takahashi
, Naoya Hosono
, Tatsuhiko Tsunoda
, Naoyuki Kamatani
, Sun Young Kong
, Hidewaki Nakagawa
, Ri Cui
, Chizu Tanikawa
, Masao Seto
, Yasuo Morishima
, Michiaki Kubo
, Yusuke Nakamura
, Koichi Matsuda

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

25 被引用数 (Scopus)

抄録

Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10^-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10^-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.

本文言語	英語
ページ（範囲）	436-439
ページ数	4
ジャーナル	Journal of Human Genetics
巻	56
号	6
DOI	https://doi.org/10.1038/jhg.2011.35
出版ステータス	出版済み - 06-2011
外部発表	はい

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遺伝学
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10.1038/jhg.2011.35

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@article{0960f86cf564416dbfaf3249ed0c18bf,

title = "Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility",

abstract = "Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 {\texttimes} 10-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 {\texttimes} 10-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.",

author = "Vinod Kumar and Keitaro Matsuo and Atsushi Takahashi and Naoya Hosono and Tatsuhiko Tsunoda and Naoyuki Kamatani and Kong, \{Sun Young\} and Hidewaki Nakagawa and Ri Cui and Chizu Tanikawa and Masao Seto and Yasuo Morishima and Michiaki Kubo and Yusuke Nakamura and Koichi Matsuda",

year = "2011",

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doi = "10.1038/jhg.2011.35",

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T1 - Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

AU - Kumar, Vinod

AU - Matsuo, Keitaro

AU - Takahashi, Atsushi

AU - Hosono, Naoya

AU - Tsunoda, Tatsuhiko

AU - Kamatani, Naoyuki

AU - Kong, Sun Young

AU - Nakagawa, Hidewaki

AU - Cui, Ri

AU - Tanikawa, Chizu

AU - Seto, Masao

AU - Morishima, Yasuo

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Matsuda, Koichi

PY - 2011/6

Y1 - 2011/6

N2 - Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.

AB - Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10-7 and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10-6 and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis.

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EP - 439

JO - Journal of Human Genetics

JF - Journal of Human Genetics

IS - 6

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Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility

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