Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells

Naohisa Oku, Kozo Kaibuchi, Yasuo Fukumoto, Yuichi Hori, Hiroyuki Fujioka, Yoshimi Takai

研究成果: Article査読

1 被引用数 (Scopus)

抄録

To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-rasval12 complementary DNA (cDNA). The results indicate that the c-Ha-rasval12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.

本文言語English
ページ(範囲)148-152
ページ数5
ジャーナルFEBS Letters
269
1
DOI
出版ステータスPublished - 20-08-1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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