Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells

Naohisa Oku; Kozo Kaibuchi; Yasuo Fukumoto; Yuichi Hori; Hiroyuki Fujioka; Yoshimi Takai

doi:10.1016/0014-5793(90)81141-A

Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells

Naohisa Oku
, Kozo Kaibuchi
, Yasuo Fukumoto
, Yuichi Hori
, Hiroyuki Fujioka
, Yoshimi Takai

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

抄録

To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-ras^val12 complementary DNA (cDNA). The results indicate that the c-Ha-ras^val12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein II_A gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.

本文言語	英語
ページ（範囲）	148-152
ページ数	5
ジャーナル	FEBS Letters
巻	269
号	1
DOI	https://doi.org/10.1016/0014-5793(90)81141-A
出版ステータス	出版済み - 20-08-1990
外部発表	はい

All Science Journal Classification (ASJC) codes

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

文献へのアクセス

10.1016/0014-5793(90)81141-A

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引用スタイル

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title = "Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells",

abstract = "To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-rasval12 complementary DNA (cDNA). The results indicate that the c-Ha-rasval12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.",

author = "Naohisa Oku and Kozo Kaibuchi and Yasuo Fukumoto and Yuichi Hori and Hiroyuki Fujioka and Yoshimi Takai",

note = "Funding Information: AcknowledgementsW: e greatlyt hank Dr F. Tamanoif or the c-Ha-rus cDNA clones, Dr K. Arai for the pcDSRcve xpressionp lasmid, pSV2CAT, pRSVCAT, c-fos-luciferasea nd pRSV-luciferase, Dr I.M. Verma for c=fo.rCATD, r K. Nose for pMTCAT and Dr R.H. Goodman for the somatostatin-CAT. We are grateful to J. Yamaguchif or her skillful secretariaal ssistanceT. his investigation was supportedb y Grants-in-Aid for ScientificR esearcha nd Cancer Research from the Ministry of Education, Sciencea nd Culture, Japan (1989)G, rants-in-Aidf or Abnormalitiesin HormoneR eceptor Mechanisms (1989), CardiovascularD iseases( 1989)a nd Cancer Researchfr om the Ministry of Healtha ndW elfare,J apan (1989a) nd by grants from the Yamanouchi Foundation for Research on Metabolic Disease( 1989),t he ResearchP rogram on Cell Calcium Signal in the CardiovasculaSr ystem( 1989)a nd the Foundationf or Promotion of CancerR esearch,J apan (1989).",

year = "1990",

month = aug,

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doi = "10.1016/0014-5793(90)81141-A",

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T1 - Comparison of the mode of action of ras p21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells

AU - Oku, Naohisa

AU - Kaibuchi, Kozo

AU - Fukumoto, Yasuo

AU - Hori, Yuichi

AU - Fujioka, Hiroyuki

AU - Takai, Yoshimi

N1 - Funding Information: AcknowledgementsW: e greatlyt hank Dr F. Tamanoif or the c-Ha-rus cDNA clones, Dr K. Arai for the pcDSRcve xpressionp lasmid, pSV2CAT, pRSVCAT, c-fos-luciferasea nd pRSV-luciferase, Dr I.M. Verma for c=fo.rCATD, r K. Nose for pMTCAT and Dr R.H. Goodman for the somatostatin-CAT. We are grateful to J. Yamaguchif or her skillful secretariaal ssistanceT. his investigation was supportedb y Grants-in-Aid for ScientificR esearcha nd Cancer Research from the Ministry of Education, Sciencea nd Culture, Japan (1989)G, rants-in-Aidf or Abnormalitiesin HormoneR eceptor Mechanisms (1989), CardiovascularD iseases( 1989)a nd Cancer Researchfr om the Ministry of Healtha ndW elfare,J apan (1989a) nd by grants from the Yamanouchi Foundation for Research on Metabolic Disease( 1989),t he ResearchP rogram on Cell Calcium Signal in the CardiovasculaSr ystem( 1989)a nd the Foundationf or Promotion of CancerR esearch,J apan (1989).

PY - 1990/8/20

Y1 - 1990/8/20

N2 - To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-rasval12 complementary DNA (cDNA). The results indicate that the c-Ha-rasval12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.

AB - To compare the mode of action of ras p21 with those of protein kinases A and C in the regulation of gene expression in NIH/3T3 cells, we investigated the transcriptional activity of various enhancer/promoters and enhancer motifs in the cells transfected with the c-Ha-rasval12 complementary DNA (cDNA). The results indicate that the c-Ha-rasval12 protein stimulates the enhancer/promoters of the c-fos gene, the metallothionein IIA gene, the simian virus 40 (SV40) virus genome and the Rous sarcoma (RS) virus genome, and the serum-response element and the 12-O-tetradecanoylphorbol-13-acetate (TPA)-response element in a manner independent of protein kinases A and C in NIH/3T3 cells.

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