Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action

Toshitaka Nabeshima, Yamada Shigeyuki Yamada, Sugimoto Akira Sugimoto, Matsuno Kiyoshi Matsuno, Kameyama Tsutomu Kameyama

研究成果: Article

13 引用 (Scopus)

抄録

The antinociceptive, tolerance-developing and anti-withdrawal activities of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzo-thiadiazole] were investigated by comparing its effects with those of morphine and clonidine in tail-flick-, hot plate-, acetic acid-induced writhing-, and naloxone-precipitated withdrawal jumping-tests. The antinociceptive action of tizanidine was not altered by naloxone, while that of morphine was antagonized. Tolerance to the tizanidine-induced antinociceptive action and to motor incoordination was developed by successive administration of tizanidine. In the tizanidine-tolerant mice, the antinociceptive action of morphine was significantly decreased, but not sleeping time induced by pentobarbital. The action of tizanidine was not modified in the morphine-tolerant mice. Tizanidine failed to induce morphine-withdrawal jumping and to inhibit naloxone-precip3tated withdrawal jumping in the morphine-dependent mice. Cross tolerance to the antinociceptive action induced by tizanidine and clonidine was developed. These results suggest that α2-adrenoreceptors may be involved in the action mechanism of tizanidine, but not opioid receptors. Functional tolerance to tizanidine action may be developed by successive administration of tizanidine.

元の言語English
ページ(範囲)835-841
ページ数7
ジャーナルPharmacology, Biochemistry and Behavior
25
発行部数4
DOI
出版物ステータスPublished - 01-01-1986
外部発表Yes

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Morphine
Naloxone
Clonidine
tizanidine
Thiadiazoles
Opioid Receptors
Pentobarbital
Ataxia
Acetic Acid
Tail

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

これを引用

Nabeshima, Toshitaka ; Shigeyuki Yamada, Yamada ; Akira Sugimoto, Sugimoto ; Kiyoshi Matsuno, Matsuno ; Tsutomu Kameyama, Kameyama. / Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action. :: Pharmacology, Biochemistry and Behavior. 1986 ; 巻 25, 番号 4. pp. 835-841.
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Comparison of tizanidine and morphine with regard to tolerance-developing ability to antinociceptive action. / Nabeshima, Toshitaka; Shigeyuki Yamada, Yamada; Akira Sugimoto, Sugimoto; Kiyoshi Matsuno, Matsuno; Tsutomu Kameyama, Kameyama.

:: Pharmacology, Biochemistry and Behavior, 巻 25, 番号 4, 01.01.1986, p. 835-841.

研究成果: Article

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