Comprehensive analysis of kinase-oriented phospho-signalling pathways

Mutsuki Amano, Tomoki Nishioka, Daisuke Tsuboi, Keisuke Kuroda, Yasuhiro Funahashi, Yukie Yamahashi, Kozo Kaibuchi

研究成果: Review article査読

6 被引用数 (Scopus)

抄録

Accumulating information on eukaryotic protein phosphorylation implies a large and complicated phospho-signalling network in various cellular processes. Although a large number of protein phosphorylation sites have been detected, their physiological consequences and the linkage between each phosphorylation site and the responsible protein kinase remain largely unexplored. To understand kinase-oriented phospho-signalling pathways, we have developed novel substrate screening technologies. In this review, we described the in vitro and in vivo screening methods named kinase-interacting substrate screening analysis and kinase-oriented substrate screening analysis, respectively.

本文言語English
ページ(範囲)301-307
ページ数7
ジャーナルJournal of Biochemistry
165
4
DOI
出版ステータスPublished - 01-04-2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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