@article{9d266c2cfa85435ab5a5e0c32b0822c4,
title = "Comprehensive behavioral phenotyping of calpastatin-knockout mice.",
abstract = "Calpastatin is an endogenous inhibitor of calpain, intracellular calcium-activated protease. It has been suggested to be involved in molecular mechanisms of long-term plasticity and excitotoxic pathways. However, functions of calpastatin in vivo are still largely unknown. To examine the physiological roles of calpastatin, we subjected calpastatin-knockout mice to a comprehensive behavioral test battery. Calpastatin-knockout mice showed decreased locomotor activity under stressful environments, and decreased acoustic startle response, but we observed no significant change in hippocampus-dependent memory function. These results suggest that calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function.",
author = "Ryuichi Nakajima and Keizo Takao and Huang, {Shu Ming} and Jiro Takano and Nobuhisa Iwata and Tsuyoshi Miyakawa and Saido, {Takaomi C.}",
note = "Funding Information: We thank Misaki Sekiguchi, Ryo Fujioka, Hiroshi Ougino and Masahiro Nakao for technical assistance. We also thank Alan Fine, Lee Ellis, Takashi Saito, Hussam Jourdi and Marcin Sawicki for the valuable comments during the preparation of the manuscript. This work was supported by Grant-in-Aid for Young Scientists (A) (#16680015), Grant-in-Aid for Exploratory Research (#16653065), Grant-in-Aid for Scientific Research on Priority Areas (#18023022, #18016012, #18053015 and IBR-shien) from Ministry of Education, Culture, Sports, Science and Technology in Japan, National Alliance for Research on Schizophrenia and Depression (NARSAD), Grant-in-Aid from Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO), Grant-in-Aid from Neuroinformatics Japan Center (NIJC), Grant-in-Aid from Institute for Bio- informatics Research and Development (BIRD) & CREST of Japan Science and Technology Agency, and RIKEN special postdoctoral researcher (SPDR) fellowship.",
year = "2008",
doi = "10.1186/1756-6606-1-7",
language = "English",
volume = "1",
pages = "7",
journal = "Molecular brain",
issn = "1756-6606",
publisher = "BioMed Central",
}