Comprehensive signal detection of delirium-associated medication using the Food and Drug Administration Adverse Event Reporting System

Masakazu Hatano, Rintaro Sogawa, Kenji Shin, Satoru Esumi, Akira Ishikawa, Ryosuke Mizumura, Haruna Araki, Shigeki Yamada

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Objective: Several medications are associated with delirium; however, studies with adequate statistical power are limited, and it is difficult to determine the effects of the various concomitant medications used in clinical practice. Therefore, in this study, we aimed to comprehensively evaluate the safety signals of delirium-associated drugs using a spontaneous adverse event reporting system. Method: The JAPIC AERS (Food and Drug Administration Adverse Event Reporting System pre-processed by the Japan Pharmaceutical Information Center) was used for the analysis in this pharmacovigilance study. The reporting odds ratio (ROR) for delirium was adjusted for using multivariate logistic regression analysis with sex, age, indication, and melatonin receptor agonist use, and 22 drug categories were targeted as covariates. Results: After excluding patients with missing information, 7,527,568 patients were included in the study. Delirium signals were detected even after adjusting for covariates in 17 drug categories, including benzodiazepines (adjusted ROR, 1.76; 95% confidence interval [CI], 1.64–1.89), opioids (adjusted ROR, 4.42; 95% CI, 4.21–4.64), and tricyclic antidepressants (adjusted ROR, 2.44; 95% CI, 2.20–2.71). Conclusions: These findings suggest that many drug classes, such as benzodiazepines, are independent risk factors for delirium and strengthen the evidence of an association between delirium and medications.

本文言語英語
ページ(範囲)50-55
ページ数6
ジャーナルGeneral Hospital Psychiatry
90
DOI
出版ステータス出版済み - 01-09-2024

All Science Journal Classification (ASJC) codes

  • 精神医学および精神衛生

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