COMT gene val158met polymorphism in patients with dyspeptic symptoms

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Fangyu Wang, Ichiro Hirata

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Background/Aims: The role of genetics in the susceptibility to functional dyspepsia (FD) is unclear. Catechol-O-methyltransferase (COMT) has been an important enzyme in brain gut axis and pain sensitivity. Polymorphism in codon 158 of the COMT gene influences its activity. This study aimed to clarify the association between COMT polymorphism and dyspepsia in a Japanese population. Methodology: 91 dyspeptics and 94 non-dyspeptic subjects enrolled in this study. Dyspeptic symptoms were divided into 9 categories. COMT gene val158met polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism. Results: The frequency of Met carriers was lower in over all dyspeptics than healthy control but the difference was not significant (OR=0.79, 95%CI=0.44-1.41) However, when the interaction between age, gender, H. pylori infection status and the number of COMT 158Met alleles was assessed using ANOVA, a slight interaction with gender + age + COMT polymorphism was found in relation to overall dyspeptics (p=0.0476) No correlation was found between COMT polymorphism and any of 9 symptoms. Conclusions: The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age. The role of genetics in the development of dyspepsia needs to further evaluation.

本文言語English
ページ(範囲)979-982
ページ数4
ジャーナルHepato-gastroenterology
55
84
出版ステータスPublished - 01-05-2008

All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 消化器病学

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