抄録
The effect of lectins on the formation of osteoclasts in RAW 264.7 mouse macrophage cells was examined. Concanavalin A (Con A) induced the formation of multinucleated giant cells (MGC) whereas pokeweed mitogen and phytohemagglutinin did not do it. Con A-induced MGC were positive for tartrate-resistant acid phosphatase (TRAP) activity, a histochemical marker of osteoclasts. Murine splenic macrophages differentiated into TRAP-positive and multinucleated cells in response to Con A whereas peritoneal macrophages did not. The culture supernatant from Con A-stimulated RAW 264.7 cells did not cause the MGC formation. The relationship between Con A-induced GMC formation and osteoclastgenesis is discussed.
本文言語 | English |
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ページ(範囲) | 103-107 |
ページ数 | 5 |
ジャーナル | Immunopharmacology and Immunotoxicology |
巻 | 31 |
号 | 1 |
DOI | |
出版ステータス | Published - 03-2009 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Toxicology
- Pharmacology