Concentration of transforming growth factor β2 in aqueous humor

Naoki Yamamoto, Koichiro Itonaga, Tohru Marunouchi, Kiyoyuki Majima

研究成果: Article査読

47 被引用数 (Scopus)


The total transforming growth factor (TGF) β2 concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-β2 concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-β2.

ジャーナルOphthalmic Research
出版ステータスPublished - 2005

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

フィンガープリント 「Concentration of transforming growth factor β<sub>2</sub> in aqueous humor」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。