Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria

Juliette H. Hughes, Ke Liu, Antonius Plagge, Peter J.M. Wilson, Hazel Sutherland, Brendan P. Norman, Andrew T. Hughes, Craig M. Keenan, Anna M. Milan, Takao Sakai, Lakshminarayan R. Ranganath, James A. Gallagher, George Bou-Gharios