Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease

Tsuneyuki Mita, Yoko Furukawa-Hibi, Hideyuki Takeuchi, Hisashi Hattori, Kiyofumi Yamada, Hideharu Hibi, Minoru Ueda, Akihito Yamamoto

研究成果: ジャーナルへの寄稿学術論文査読

135 被引用数 (Scopus)

抄録

Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by a decline in cognitive abilities and the appearance of β-amyloid plaques in the brain. Although the pathogenic mechanisms associated with AD are not fully understood, activated microglia releasing various neurotoxic factors, including pro-inflammatory cytokines and oxidative stress mediators, appear to play major roles. Here, we investigated the therapeutic benefits of a serum-free conditioned medium (CM) derived from the stem cells of human exfoliated deciduous teeth (SHEDs) in a mouse model of AD. The intranasal administration of SHEDs in these mice resulted in substantially improved cognitive function. SHED-CM contained factors involved in multiple neuroregenerative mechanisms, such as neuroprotection, axonal elongation, neurotransmission, the suppression of inflammation, and microglial regulation. Notably, SHED-CM attenuated the pro-inflammatory responses induced by β-amyloid plaques, and generated an anti-inflammatory/tissue-regenerating environment, which was accompanied by the induction of anti-inflammatory M2-like microglia. Our data suggest that SHED-CM may provide significant therapeutic benefits for AD.

本文言語英語
ページ(範囲)189-197
ページ数9
ジャーナルBehavioural Brain Research
293
DOI
出版ステータス出版済み - 05-10-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 行動神経科学

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