Conditioned Suppression of Motility: Possibility for Evaluation of Learning and Memory in Mice

Toshitaka Nabeshima, Teruo Kozawa, Tsutomu Kameyama

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Mice showed a marked suppression of motility when placed in the same environment where they had been given electric shocks (ES) 24 h before. This conditioned suppression of motility (CS) was attenuated by the administration of cycloheximide (CXM, 25 - 150 mg/kg) immediately after ES treatment in a dose-dependent manner. CXM (50 mg/kg) administered 1 h after ES failed to attenuate the CS. These effects seem to be caused by retrograde amnesia. Furthermore the amnesic action of CXM was antagonized by naloxone (10 mg/kg), which did not affect CS. Physostigmine (0.2 mg/kg), propranolol (1 mg/kg) and cyproheptadine (2 mg/kg) did not antagonize CXM-induced amnesia significantly. In the same way the arnnssia inducing actions of phencyclidine and scopolamine were detected. The CS method seems to be useful to examine learning and memory performances in animals and has the advantage that evaluation is extremely easy.

本文言語English
ページ(範囲)779-784
ページ数6
ジャーナルJournal of Pharmacobio-Dynamics
11
12
DOI
出版ステータスPublished - 01-02-1988

All Science Journal Classification (ASJC) codes

  • Pharmacology

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