Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis

Kaori Maeyama, Kazumi Tomioka, Hiroaki Nagase, Mieko Yoshioka, Yasuko Takagi, Takeshi Kato, Masami Mizobuchi, Shinji Kitayama, Satoshi Takada, Masashi Nagai, Nana Sakakibara, Masahiro Nishiyama, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

研究成果: Article

12 引用 (Scopus)

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Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

元の言語English
ページ(範囲)1483-1491
ページ数9
ジャーナルJournal of Autism and Developmental Disorders
48
発行部数5
DOI
出版物ステータスPublished - 01-05-2018

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology

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    Maeyama, K., Tomioka, K., Nagase, H., Yoshioka, M., Takagi, Y., Kato, T., Mizobuchi, M., Kitayama, S., Takada, S., Nagai, M., Sakakibara, N., Nishiyama, M., Taniguchi-Ikeda, M., Morioka, I., Iijima, K., & Nishimura, N. (2018). Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis. Journal of Autism and Developmental Disorders, 48(5), 1483-1491. https://doi.org/10.1007/s10803-017-3412-x