Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis

Kaori Maeyama, Kazumi Tomioka, Hiroaki Nagase, Mieko Yoshioka, Yasuko Takagi, Takeshi Kato, Masami Mizobuchi, Shinji Kitayama, Satoshi Takada, Masashi Nagai, Nana Sakakibara, Masahiro Nishiyama, Mariko Taniguchi-Ikeda, Ichiro Morioka, Kazumoto Iijima, Noriyuki Nishimura

研究成果: Article

6 引用 (Scopus)

抄録

Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

元の言語English
ページ(範囲)1483-1491
ページ数9
ジャーナルJournal of Autism and Developmental Disorders
48
発行部数5
DOI
出版物ステータスPublished - 01-05-2018

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Cytomegalovirus Infections
Autistic Disorder
Meta-Analysis
Library Science
PubMed
Observational Studies
Autism Spectrum Disorder
Databases

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology

これを引用

Maeyama, Kaori ; Tomioka, Kazumi ; Nagase, Hiroaki ; Yoshioka, Mieko ; Takagi, Yasuko ; Kato, Takeshi ; Mizobuchi, Masami ; Kitayama, Shinji ; Takada, Satoshi ; Nagai, Masashi ; Sakakibara, Nana ; Nishiyama, Masahiro ; Taniguchi-Ikeda, Mariko ; Morioka, Ichiro ; Iijima, Kazumoto ; Nishimura, Noriyuki. / Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder : Systematic Review and Meta-Analysis. :: Journal of Autism and Developmental Disorders. 2018 ; 巻 48, 番号 5. pp. 1483-1491.
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Maeyama, K, Tomioka, K, Nagase, H, Yoshioka, M, Takagi, Y, Kato, T, Mizobuchi, M, Kitayama, S, Takada, S, Nagai, M, Sakakibara, N, Nishiyama, M, Taniguchi-Ikeda, M, Morioka, I, Iijima, K & Nishimura, N 2018, 'Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis', Journal of Autism and Developmental Disorders, 巻. 48, 番号 5, pp. 1483-1491. https://doi.org/10.1007/s10803-017-3412-x

Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder : Systematic Review and Meta-Analysis. / Maeyama, Kaori; Tomioka, Kazumi; Nagase, Hiroaki; Yoshioka, Mieko; Takagi, Yasuko; Kato, Takeshi; Mizobuchi, Masami; Kitayama, Shinji; Takada, Satoshi; Nagai, Masashi; Sakakibara, Nana; Nishiyama, Masahiro; Taniguchi-Ikeda, Mariko; Morioka, Ichiro; Iijima, Kazumoto; Nishimura, Noriyuki.

:: Journal of Autism and Developmental Disorders, 巻 48, 番号 5, 01.05.2018, p. 1483-1491.

研究成果: Article

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T2 - Systematic Review and Meta-Analysis

AU - Maeyama, Kaori

AU - Tomioka, Kazumi

AU - Nagase, Hiroaki

AU - Yoshioka, Mieko

AU - Takagi, Yasuko

AU - Kato, Takeshi

AU - Mizobuchi, Masami

AU - Kitayama, Shinji

AU - Takada, Satoshi

AU - Nagai, Masashi

AU - Sakakibara, Nana

AU - Nishiyama, Masahiro

AU - Taniguchi-Ikeda, Mariko

AU - Morioka, Ichiro

AU - Iijima, Kazumoto

AU - Nishimura, Noriyuki

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AB - Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07–41.66) was indicated, too few events (0–2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue.

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