Continuous infusion of β-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration

Atsumi Nitta, Taneo Fukuta, Takaaki Hasegawa, Toshitaka Nabeshima

研究成果: Article査読

144 被引用数 (Scopus)

抄録

To investigate the toxicity of β-amyloid protein, a component of the senile plaques in Alzheimer's disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in β-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, β-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that β-amyloid protein produces some damage in the central nervous system in vivo.

本文言語English
ページ(範囲)51-57
ページ数7
ジャーナルJapanese Journal of Pharmacology
73
1
DOI
出版ステータスPublished - 1997

All Science Journal Classification (ASJC) codes

  • 薬理学

フィンガープリント

「Continuous infusion of β-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル