Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

Gina K. Thomson; James W. Snyder; Christi L. McElheny; Kenneth S. Thomson; Yohei Doi

doi:10.1128/JCM.02739-15

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam'β-Lactamase Inhibitor Combinations

Gina K. Thomson
, James W. Snyder
, Christi L. McElheny
, Kenneth S. Thomson
, Yohei Doi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

抄録

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, bla_KPC-18 and bla_VIM-1. Whole-genome sequencing localized bla_KPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.

本文言語	英語
ページ（範囲）	791-794
ページ数	4
ジャーナル	Journal of clinical microbiology
巻	54
号	3
DOI	https://doi.org/10.1128/JCM.02739-15
出版ステータス	出版済み - 03-2016
外部発表	はい

All Science Journal Classification (ASJC) codes

微生物学（医療）

文献へのアクセス

10.1128/JCM.02739-15

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引用スタイル

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abstract = "Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, blaKPC-18 and blaVIM-1. Whole-genome sequencing localized blaKPC-18 to the chromosome and blaVIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam'β-lactamase inhibitor combinations.",

author = "Thomson, \{Gina K.\} and Snyder, \{James W.\} and McElheny, \{Christi L.\} and Thomson, \{Kenneth S.\} and Yohei Doi",

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AU - Doi, Yohei

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