Correlation between macular volume and focal macular electroretinogram in patients with retinitis pigmentosa

Tadasu Sugita, Mineo Kondo, Chang Hua Piao, Yasuki Ito, Hiroko Terasaki

研究成果: Article査読

43 被引用数 (Scopus)

抄録

PURPOSE. To determine whether a significant correlation exists between the morphology of the macula measured by optical coherence tomography (OCT) and the amplitude of focal macular electroretinograms (fmERGs) in patients with retinitis pigmentosa (RP). METHODS. fmERGs were recorded in 43 patients with RP and 43 age-similar normal subjects, with a 15° stimulus spot, 5.6 to 5.8 mm in diameter on the fundus. The sum of the volume of the neural retina in the central 6 mm (total macular volume) was measured with the OCT system. The length of the photoreceptor inner segment/outer segment junction (IS/OS line) in a 6-mm diameter macular area was also measured in the OCT images. RESULTS. There was a weak correlation between the total macular volume and the fmERG amplitudes (correlation coefficient, 0.46 for the a-wave and 0.54 for the b-wave). The fmERG amplitudes in the patients with RP with IS/OS line longer than 2 mm were significantly larger than those in patients with RP with IS/OS line shorter than 2 mm, but the correlations between these two factors were weak. One major reason for the low correlations between the macular morphology and fmERGs was that there were some patients with RP who had normal macular volume and long IS/OS line, but had severely reduced focal macular ERGs. CONCLUSIONS. Although the macular volume and length of the IS/OS line correlated weakly with the amplitude of the fmERGs, a preserved macular morphology does not necessarily guarantee normal-amplitude fmERGs in patients with RP.

本文言語English
ページ(範囲)3551-3558
ページ数8
ジャーナルInvestigative Ophthalmology and Visual Science
49
8
DOI
出版ステータスPublished - 08-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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