Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment

Taichi Tsunekawa, Hiroki Kaneko, Kei Takayama, Shiang Jyi Hwang, Akio Oishi, Yosuke Nagasaka, Fuxiang Ye, Takeshi Iwase, Norie Nonobe, Shinji Ueno, Yasuki Ito, Shunsuke Yasuda, Toshiyuki Matsuura, Hideyuki Shimizu, Ayana Suzumura, Keiko Kataoka, Hiroko Terasaki

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Purpose. We had earlier reported positive hsa-miR-148a-3p expression in eyes with rhegmatogenous retinal detachment (RRD) and its involvement in the epithelial-mesenchymal transition of retinal pigment epithelium in vitro. Here we investigated the association of hsa-miR-148a-3p expression levels in the vitreous fluid of patients with RRD with severity of RRD. Methods. The hsa-miR-148a-3p expression levels in the vitreous fluid, range (degree) of retinal detachment (RD), and pixels of retinal break were measured in 27 eyes with RRD. The association of hsa-miR-148a-3p expression levels with other factors was evaluated by multiple regression analysis. Results. The hsa-miR-148a-3p expression levels, time from onset of RRD to vitrectomy, range of RD, and pixels of retinal breaks were 23.68±43.00, 12.07±15.36 days, 155.85±86.67 degrees, and 37000±67100 pixels, respectively. Five eyes with RRD had vitreous hemorrhage preoperatively. The hsa-miR-148a-3p expression levels were significantly associated with pixels of retinal breaks (β=0.699) and the time from onset of RRD to vitrectomy (β=0.358) but not with the range of RD or presence of vitreous hemorrhage. Conclusion. The hsa-miR-148a-3p expression levels in the vitreous fluid were significantly associated with the size of retinal break and disease duration.

本文言語English
論文番号3427319
ジャーナルBioMed Research International
2017
DOI
出版ステータスPublished - 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)

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