Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy

Mikio Kawamura, Susumu Saigusa, Yuji Toiyama, Koji Tanaka, Yoshinaga Okugawa, Junic Hiro, Keiichi Uchida, Yasuhiko Mohri, Yasuhiro Inoue, Masato Kusunoki

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Background: Metastasis associated in colon cancer 1 (MACC1) is a recently identified gene that plays a key role in regulating hepatocyte growth factor-MET signaling. In this study, we demonstrated the correlation and the clinical significance of MACC1 and MET expression in rectal cancer patients treated with chemoradiotherapy (CRT) followed by surgery. Materials and Methods: The expression of MACC1 and MET mRNA in residual cancer cells from 52 patients after CRT was determined by quantitative real-time polymerase chain reaction. Protein expression was also investigated by immunohistochemical staining. Results: MACC1 and MET expressions were positively correlated. Furthermore, these proteins were also co-expressed in immunohistochemical analyses. High expression of MACC1 or MET was associated with reduced relapse-free survival and the prognosis was worse when both genes were highly expressed. Conclusion: Evaluation of MACC1 and MET expression may be useful for predicting prognosis in patients with rectal cancer treated with CRT followed by surgery.

本文言語English
ページ(範囲)1527-1531
ページ数5
ジャーナルAnticancer research
32
4
出版ステータスPublished - 04-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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