CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning

Makoto Mizuno, Kiyofumi Yamada, Naoya Maekawa, Kuniaki Saito, Mitsuru Seishima, Toshitaka Nabeshima

研究成果: Article

161 引用 (Scopus)

抄録

Regulation of gene transcription via the cyclic adenosine 3′,5′-monophosphate (cAMP)-mediated second messenger pathway has been implicated in learning and memory. Although the cAMP response element-binding protein (CREB) is an important transcription factor involved in long-term memory, it remains to be determined whether the CREB-dependent events are attributed to spatial learning and memory in a radial arm maze. Here we demonstrate that cAMP-dependent protein kinase A (PKA) and CREB are activated in the course of spatial learning. The radial maze training in rats resulted in a significant increase in PKA and CREB phosphorylation in the hippocampus in the course of spatial learning, which was followed by spatial memory formation. On the other hand, neither the phosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) nor the mRNA level of brain-derived neurotrophic factor was significantly affected. These results suggest that activation of the PKA/CREB signaling pathway in the hippocampus plays an important role in spatial memory formation.

元の言語English
ページ(範囲)135-141
ページ数7
ジャーナルBehavioural Brain Research
133
発行部数2
DOI
出版物ステータスPublished - 18-07-2002
外部発表Yes

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Cyclic AMP Response Element-Binding Protein
Hippocampus
Cyclic AMP-Dependent Protein Kinases
Phosphorylation
Adenosine
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Long-Term Memory
Brain-Derived Neurotrophic Factor
Extracellular Signal-Regulated MAP Kinases
Response Elements
Second Messenger Systems
Carrier Proteins
Transcription Factors
Learning
Messenger RNA
Spatial Learning
Genes
Spatial Memory

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

これを引用

Mizuno, Makoto ; Yamada, Kiyofumi ; Maekawa, Naoya ; Saito, Kuniaki ; Seishima, Mitsuru ; Nabeshima, Toshitaka. / CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. :: Behavioural Brain Research. 2002 ; 巻 133, 番号 2. pp. 135-141.
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CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. / Mizuno, Makoto; Yamada, Kiyofumi; Maekawa, Naoya; Saito, Kuniaki; Seishima, Mitsuru; Nabeshima, Toshitaka.

:: Behavioural Brain Research, 巻 133, 番号 2, 18.07.2002, p. 135-141.

研究成果: Article

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AU - Seishima, Mitsuru

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