Cripto-1: An embryonic gene that promotes tumorigenesis

Nadia Pereira De Castro, Maria Cristina Rangel, Tadahiro Nagaoka, David S. Salomon, Caterina Bianco

研究成果: Review article

35 引用 (Scopus)

抄録

Several studies have shown that cell fate regulation during embryonic development and oncogenic transformation share common regulatory mechanisms and signaling pathways. Indeed, an embryonic gene member of the EGF-Cripto-1/FRL1/ Cryptic family, Cripto-1, has been implicated in embryogenesis and in carcinogenesis. Cripto-1 together with the TGF- ligand Nodal is a key regulator of embryonic development and is a marker of undifferentiated human and mouse embryonic stem cells. While Cripto-1 expression is very low in normal adult tissues, Cripto-1 is re-expressed at high levels in several different human tumors, modulating cancer cell proliferation, migration, epithelial-to- mesenchymal transition and stimulating tumor angiogenesis. Therefore, inhibition of Cripto-1 expression using blocking antibodies or antisense expression vectors might be a useful modality not only to target fully differentiated cancer cells but also to target a subpopulation of tumor cells with stem-like characteristics.

元の言語English
ページ(範囲)1127-1142
ページ数16
ジャーナルFuture Oncology
6
発行部数7
DOI
出版物ステータスPublished - 01-07-2010
外部発表Yes

Fingerprint

Carcinogenesis
Embryonic Development
Genes
Neoplasms
Blocking Antibodies
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Epidermal Growth Factor
Cell Movement
Cell Proliferation
Ligands

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

De Castro, N. P., Rangel, M. C., Nagaoka, T., Salomon, D. S., & Bianco, C. (2010). Cripto-1: An embryonic gene that promotes tumorigenesis. Future Oncology, 6(7), 1127-1142. https://doi.org/10.2217/fon.10.68
De Castro, Nadia Pereira ; Rangel, Maria Cristina ; Nagaoka, Tadahiro ; Salomon, David S. ; Bianco, Caterina. / Cripto-1 : An embryonic gene that promotes tumorigenesis. :: Future Oncology. 2010 ; 巻 6, 番号 7. pp. 1127-1142.
@article{ede9ed7dfbb24b7d8ea12523e9d72a7c,
title = "Cripto-1: An embryonic gene that promotes tumorigenesis",
abstract = "Several studies have shown that cell fate regulation during embryonic development and oncogenic transformation share common regulatory mechanisms and signaling pathways. Indeed, an embryonic gene member of the EGF-Cripto-1/FRL1/ Cryptic family, Cripto-1, has been implicated in embryogenesis and in carcinogenesis. Cripto-1 together with the TGF- ligand Nodal is a key regulator of embryonic development and is a marker of undifferentiated human and mouse embryonic stem cells. While Cripto-1 expression is very low in normal adult tissues, Cripto-1 is re-expressed at high levels in several different human tumors, modulating cancer cell proliferation, migration, epithelial-to- mesenchymal transition and stimulating tumor angiogenesis. Therefore, inhibition of Cripto-1 expression using blocking antibodies or antisense expression vectors might be a useful modality not only to target fully differentiated cancer cells but also to target a subpopulation of tumor cells with stem-like characteristics.",
author = "{De Castro}, {Nadia Pereira} and Rangel, {Maria Cristina} and Tadahiro Nagaoka and Salomon, {David S.} and Caterina Bianco",
year = "2010",
month = "7",
day = "1",
doi = "10.2217/fon.10.68",
language = "English",
volume = "6",
pages = "1127--1142",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "7",

}

De Castro, NP, Rangel, MC, Nagaoka, T, Salomon, DS & Bianco, C 2010, 'Cripto-1: An embryonic gene that promotes tumorigenesis', Future Oncology, 巻. 6, 番号 7, pp. 1127-1142. https://doi.org/10.2217/fon.10.68

Cripto-1 : An embryonic gene that promotes tumorigenesis. / De Castro, Nadia Pereira; Rangel, Maria Cristina; Nagaoka, Tadahiro; Salomon, David S.; Bianco, Caterina.

:: Future Oncology, 巻 6, 番号 7, 01.07.2010, p. 1127-1142.

研究成果: Review article

TY - JOUR

T1 - Cripto-1

T2 - An embryonic gene that promotes tumorigenesis

AU - De Castro, Nadia Pereira

AU - Rangel, Maria Cristina

AU - Nagaoka, Tadahiro

AU - Salomon, David S.

AU - Bianco, Caterina

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Several studies have shown that cell fate regulation during embryonic development and oncogenic transformation share common regulatory mechanisms and signaling pathways. Indeed, an embryonic gene member of the EGF-Cripto-1/FRL1/ Cryptic family, Cripto-1, has been implicated in embryogenesis and in carcinogenesis. Cripto-1 together with the TGF- ligand Nodal is a key regulator of embryonic development and is a marker of undifferentiated human and mouse embryonic stem cells. While Cripto-1 expression is very low in normal adult tissues, Cripto-1 is re-expressed at high levels in several different human tumors, modulating cancer cell proliferation, migration, epithelial-to- mesenchymal transition and stimulating tumor angiogenesis. Therefore, inhibition of Cripto-1 expression using blocking antibodies or antisense expression vectors might be a useful modality not only to target fully differentiated cancer cells but also to target a subpopulation of tumor cells with stem-like characteristics.

AB - Several studies have shown that cell fate regulation during embryonic development and oncogenic transformation share common regulatory mechanisms and signaling pathways. Indeed, an embryonic gene member of the EGF-Cripto-1/FRL1/ Cryptic family, Cripto-1, has been implicated in embryogenesis and in carcinogenesis. Cripto-1 together with the TGF- ligand Nodal is a key regulator of embryonic development and is a marker of undifferentiated human and mouse embryonic stem cells. While Cripto-1 expression is very low in normal adult tissues, Cripto-1 is re-expressed at high levels in several different human tumors, modulating cancer cell proliferation, migration, epithelial-to- mesenchymal transition and stimulating tumor angiogenesis. Therefore, inhibition of Cripto-1 expression using blocking antibodies or antisense expression vectors might be a useful modality not only to target fully differentiated cancer cells but also to target a subpopulation of tumor cells with stem-like characteristics.

UR - http://www.scopus.com/inward/record.url?scp=77954677991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954677991&partnerID=8YFLogxK

U2 - 10.2217/fon.10.68

DO - 10.2217/fon.10.68

M3 - Review article

C2 - 20624125

AN - SCOPUS:77954677991

VL - 6

SP - 1127

EP - 1142

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 7

ER -

De Castro NP, Rangel MC, Nagaoka T, Salomon DS, Bianco C. Cripto-1: An embryonic gene that promotes tumorigenesis. Future Oncology. 2010 7 1;6(7):1127-1142. https://doi.org/10.2217/fon.10.68