CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration

Takaaki Yamada, Seiji Hasegawa, Yuichi Hasebe, Mika Kawagishi-Hotta, Masaru Arima, Yohei Iwata, Tsukane Kobayashi, Shigeki Numata, Naoki Yamamoto, Satoru Nakata, Kazumitsu Sugiura, Hirohiko Akamatsu

研究成果: Article

抜粋

Melanocyte stem cells (McSCs) are localized in the bulge region of hair follicles and supply melanocytes, which determine hair color by synthesizing melanin. Ectopic differentiation of McSCs, which are usually undifferentiated in the bulge region, causes depletion of McSCs and results in hair graying. Therefore, to prevent hair graying, it is essential to maintain McSCs in the bulge region, but the mechanism of McSC maintenance remains unclear. To address this issue, we investigated the role of CXCL12, a chemokine which was previously suggested to induce migration of melanocyte lineage cells, as a niche component of McSCs. Immunohistological analysis revealed that CXCL12 was highly expressed in the bulge region of human hair follicles. CXCL12 mRNA expression level was significantly lower in white hairs plucked from human scalps than in black hairs. CXCL12 attracted the migration of early-passage normal human epidermal melanocytes (eNHEMs), an in vitro model of McSCs, which had characteristics of immature melanocyte precursors. We also found that CXCL12 suppressed their differentiation. These results suggest that CXCL12 regulates differentiation of McSCs as well as their proper localization, and maintaining McSCs by regulating CXCL12 expression level in the bulge region may be a key to preventing hair graying.

元の言語English
ページ(範囲)55-62
ページ数8
ジャーナルArchives of Dermatological Research
311
発行部数1
DOI
出版物ステータスPublished - 22-01-2019

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Yamada, T., Hasegawa, S., Hasebe, Y., Kawagishi-Hotta, M., Arima, M., Iwata, Y., Kobayashi, T., Numata, S., Yamamoto, N., Nakata, S., Sugiura, K., & Akamatsu, H. (2019). CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration. Archives of Dermatological Research, 311(1), 55-62. https://doi.org/10.1007/s00403-018-1880-2