TY - JOUR
T1 - Cyclin D1 overexpression in N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas
AU - Takasu, Shinji
AU - Tsukamoto, Tetsuya
AU - Ushijima, Toshikazu
AU - Yamashita, Satoshi
AU - Ogasawara, Naotaka
AU - Ban, Hisayo
AU - Yanai, Tokuma
AU - Masegi, Toshiaki
AU - Tatematsu, Masae
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2007/11/26
Y1 - 2007/11/26
N2 - Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas and compared with findings for β-catenin. Cyclin D1 nuclear overexpression was more frequently observed in tumors displaying nuclear (4/4=100%) and cytoplasmic (3/4=75%) β-catenin accumulation than those with membranous (3/15=20%) localization (nuclear vs. membranous, P<0.02). In the former cases it was considered that cyclin D1 was induced with β-catenin activation; in the latter, a direct or indirect pathway for cyclin D1 accumulation bypassing Wnt pathway might be involved. Cyclin D1 was also found to be accumulated in gastric glands within normal-looking mucosa, these perhaps representing preneoplastic lesions for cancers with membranous β-catenin accumulation.
AB - Changes in cell cycle regulation are involved in many human cancers, including gastric cancer. In the present study, cyclin D1 expression and localization were immunohistochemically analyzed in 23 N-methyl-N′-nitro-N-nitrosoguanidine-induced rat gastric adenocarcinomas and compared with findings for β-catenin. Cyclin D1 nuclear overexpression was more frequently observed in tumors displaying nuclear (4/4=100%) and cytoplasmic (3/4=75%) β-catenin accumulation than those with membranous (3/15=20%) localization (nuclear vs. membranous, P<0.02). In the former cases it was considered that cyclin D1 was induced with β-catenin activation; in the latter, a direct or indirect pathway for cyclin D1 accumulation bypassing Wnt pathway might be involved. Cyclin D1 was also found to be accumulated in gastric glands within normal-looking mucosa, these perhaps representing preneoplastic lesions for cancers with membranous β-catenin accumulation.
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U2 - 10.1016/j.etp.2007.06.005
DO - 10.1016/j.etp.2007.06.005
M3 - Article
C2 - 17855062
AN - SCOPUS:35648952139
SN - 0940-2993
VL - 59
SP - 171
EP - 175
JO - Experimental and Toxicologic Pathology
JF - Experimental and Toxicologic Pathology
IS - 3-4
ER -
