Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans

Hidekazu Tomimoto, Ichiro Akiguchi, Hideaki Wakita, Jin Xi Lin, Herbert Budka

研究成果: Article

82 引用 (Scopus)

抄録

Cyclooxygenase-2 (COX-2) is known to be upregulated in ischemic rodent brains, but only little information is available for the human brain. Using immunohistochemistry for COX-2, we investigated brains from control subjects and from patients with cerebrovascular diseases. COX-2 was markedly up-regulated in the neurons and endothelial cells in acute cerebral infarction, but was detected sparsely at chronic stages in these cellular compartments. In contrast, COX-2 immunoreactivity in glial cells was localized to the perinuclear region even in control brains. This immunolabeling was more intense and occurred also in the glial cytoplasm in the brains with chronic cerebral ischemia such as Binswanger's disease. Double-labeling immunohistochemistry confirmed that COX-2-immunoreactive glia were mostly microglia. These results indicate that prostanoid synthesis is up-regulated in microglia during chronic cerebral ischemia, and that these cells may be involved in tissue repair or inflammation-mediated cell responses.

元の言語English
ページ(範囲)26-30
ページ数5
ジャーナルActa Neuropathologica
99
発行部数1
DOI
出版物ステータスPublished - 01-01-2000

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Microglia
Cyclooxygenase 2
Brain Ischemia
Neuroglia
Brain
Immunohistochemistry
Cerebrovascular Disorders
Vascular Dementia
Cerebral Infarction
Prostaglandins
Rodentia
Cytoplasm
Endothelial Cells
Inflammation
Neurons

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

これを引用

Tomimoto, Hidekazu ; Akiguchi, Ichiro ; Wakita, Hideaki ; Lin, Jin Xi ; Budka, Herbert. / Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans. :: Acta Neuropathologica. 2000 ; 巻 99, 番号 1. pp. 26-30.
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Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans. / Tomimoto, Hidekazu; Akiguchi, Ichiro; Wakita, Hideaki; Lin, Jin Xi; Budka, Herbert.

:: Acta Neuropathologica, 巻 99, 番号 1, 01.01.2000, p. 26-30.

研究成果: Article

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