Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications

Akio Kimura; Masao Takemura; Yasuko Yamamoto; Yuichi Hayashi; Kuniaki Saito; Takayoshi Shimohata

doi:10.1016/j.jneuroim.2019.576999

Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications

Akio Kimura, Masao Takemura, Yasuko Yamamoto, Yuichi Hayashi, Kuniaki Saito, Takayoshi Shimohata

研究推進ﾕﾆｯﾄ・先進診断ｼｽﾃﾑ開発分野

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

25 被引用数 (Scopus)

抄録

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.

本文言語	英語
論文番号	576999
ジャーナル	Journal of Neuroimmunology
巻	334
DOI	https://doi.org/10.1016/j.jneuroim.2019.576999
出版ステータス	出版済み - 15-09-2019

All Science Journal Classification (ASJC) codes

免疫アレルギー学
免疫学
神経学
臨床神経学

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10.1016/j.jneuroim.2019.576999

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title = "Cytokines and biological markers in autoimmune GFAP astrocytopathy: The potential role for pathogenesis and therapeutic implications",

abstract = "Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (GFAP-A) is a corticosteroid-responsive meningoencephalomyelitis with a poorly understood pathogenesis. We examined and compared the levels of cytokines and biological markers in the cerebrospinal fluid (CSF) of patients with GFAP-A and other neurological disorders. We identified four cytokines (tumor necrosis factor alpha [TNFα], Interleukin [IL]-27, IL-6, and chemokine [C-C motif] ligand 20) and three biological markers (GFAP, S100 calcium-binding protein B, and neurofilament light chain) present at elevated levels in CSF samples during the acute phase of GFAP-A. Additionally, we identified significant correlations between CSF TNFα, IL-27, IL-6, and CSF biological markers.",

author = "Akio Kimura and Masao Takemura and Yasuko Yamamoto and Yuichi Hayashi and Kuniaki Saito and Takayoshi Shimohata",

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AU - Kimura, Akio

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AU - Saito, Kuniaki

AU - Shimohata, Takayoshi

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